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AngII can be cleaved to AngIII by aminopeptidase-A, and further to AngIV and Ang3-7 by aminopeptidase N or carboxypeptidase P and prolyl-oligopeptidase, respectively

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APAP-induced necrosis of centrilobular hepatocytes necrosis releases damage-associated molecular patterns (DAMPs)

The peripheral sectors summarize six complementary therapeutic strategies: (1) Antimicrobial therapy: agents that directly reduce the anaerobic bacterial load (e.g., metronidazole) or prodrugs activated by bacterial gingipains are shown as approaches to remove the inciting infectious stimulus