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Topotecan (TPT), an inhibitor of DNA topoisomerase I, was recently discovered to downregulate ASCT2, leading to oxidative stress and apoptosis induction through the mitochondrial pathway in gastric cancer cells
doi: 10.1016/j.psj.2022.102189 109 Al-KhalaifahHSIbrahimDKamelAEAl-NasserAAbdelwarithAARoushdyEMet al
Key Takeaway: The GHK-Cu literature remains largely pre-clinical, with stability handling and sourcing variability as the two operational risk factors most likely to compromise research reproducibility
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The high frequency of the NAT2 and also NAT1 acetylation polymorphism in human population together with ubiquitous exposure to aromatic and heterocyclic amines suggest that and acetylator genotypes are important modifiers of human cancer susceptibility
