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Inflammation engulfs a substantial amount of oxygen, leading to hypoxia and acidic conditions in the 1 system [13], which subsequently triggers the generation of reactive oxygen species (ROS), angiogenesis, and infiltration by inflammatory cells

A retrospective study looking at concomitant use of proton pump inhibitors (PPIs) alongside metformin in 614 people with type 2 diabetes in the US found a significant reduction in B12 levels of 34% in patients taking both medications, compared to controls taking either drug alone (Long et al, 2012)

They found a similar robust response in both the seizure and Alzheimers models

an Mason, R.J