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Cells respond to specific signaling intensities, and exceeding optimal ranges doesn't produce proportionally better responses

Different aspects of regulation Biochemical pathways: amino acids in stress response Stress responses in fish are characterized by a series of neuroendocrine and metabolic responses, including the activation of the hypothalamus-pituitary-interrenal (HPI) axis and the release of stress hormones such as cortisol and catecholamines, the primary stress hormones in teleosts

Uric acid can enhance MAPK pathway-mediated proliferation in rat primary vascular smooth muscle cells via controlling of mitochondria and caspase-dependent cell death

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Di Lorenzo A, Bolli E, Tarone L, Cavallo F, Conti L