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Pharmacokinetics of Metformin Gastric-Retentive Tablets in Healthy Volunteers

The G value of + 13.0 kcal/mol for p.Arg106Pro most probably underestimates the effect of the variant because the WT model has the residues 110-112 and 108-112 missing in chains A and B, respectively, and the residues around the variant, including Arg106, have high B-factors, i.e., the position of the side chain does not have high accuracy due, for example, to dynamics

For example, peptide hormones can be employed to correct hormonal imbalances, while antimicrobial peptides can be used to combat infections