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The complex pathophysiology and heterogeneity of the disease raises the speculation that combined treatment will be required for many patients

PorporaMGBrunelliRCostaGImperialeLKrasnowskaEKLundebergTet al

doi:10.1146/annurev.pharmtox.45.120403.095857

This review explores the potential of MB in medical research and clinical applications, focusing on its diagnostic and therapeutic prospects

An alternative interpretation for the first phase could be a rapid noncovalent interaction between PfGrx and GSSG in the vicinity of roGFP2, however, this seems less likely considering the smaller values for the structurally similar PfGrx mutants or, in particular, the rxYFP fusion constructs with ScGrx1 (Table 1)