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The results showed that vitamin B complex treatment reduced proinflammatory cytokine expression while increasing anti-inflammatory cytokine expression, and this led to neuroinflammation resolution

Using the clinical trial escalation protocol (2mg starting dose with 2mg increases every 4 weeks), reaching the 12mg maintenance dose takes approximately 20 weeks

This balance is what makes it suitable for multi-dose use in research protocols

10.1007/s10787-006-1531-7 [DOI] [PubMed] [Google Scholar] Sikiric P., Seiwerth S., Brcic L., Sever M., Klicek R., Radic B., et al

The most consistent finding: researchers who dose MOTS-c in the morning during fasted states report more pronounced shifts in substrate utilizationmeasured via respiratory exchange ratio (RER)than those administering it post-meal