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Genes Dev (1998) 12(24):387281.10.1101/gad.12.24.3872 130 KamuraTMaenakaKKotoshibaSMatsumotoMKohdaDConawayRCet alVHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

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ii) Anti-inflammatory and anti-fibrosis therapy should be considered in some patients with cirrhosis for whom etiological therapy is not available, or for whom liver inflammation or fibrosis remains severe after etiological therapy

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