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Although the magnitude of hydraulic resistance experienced by migrating breast cancer cells in vivo is currently unknown, mathematical modeling indicates that depending on the interstitial fluid viscosity and matrix permeability, the hydraulic resistance within 3D matrices could potentially match or even exceed that observed in microchannels [50, 203]

Sulfonylureas and Meglitinides

Cross-sectional validity of a modified Edmonton symptom assessment system in dialysis patients: a simple assessment of symptom burden

The paper reports the absence of the positive effect under twice-daily dosing rather than a measured decrement, and no head-to-head statistical comparison of the two schedules is given but even read at its most conservative, that is not how a dose-dependent hypnotic behaves