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It is not a dietary supplement, medication, or food product, and is not intended for human consumption

Risk of bias assessment Briefly, the modified Back and Downs checklist with 26 questions and four domains, which are relevant for analyzing the quality of encompassed studies (Supplementary file 2 depicts that encompassed studies presented with low reporting bias with a median score of 8 out of a probable score of 10 (overall agreement 85.67%, kappa = 0.71), good external legitimacy with median score of 2 out of 3 (overall agreement 39.13%, kappa = 0.13), excellent internal validity with median score 7 out of 7 (overall agreement 65.22%, kappa = 0.34) and low risk assortment bias with median of 5 out of possible 6 (overall agreement 56.51%, kappa = 0.19)

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By the time they reached the hospital, one of them had lost control of her neck muscles, and the other had been intubated