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The SELECT study has some limitations

B12 helps reduce homocysteine levels, an amino acid linked to heart disease

Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet

Avoid unsupported claims about their efficacy, and never handle these compounds without understanding proper reconstitution and dosing protocols

Compounded drugs are not generic versions of, and are not the same as or equivalent to, FDA-approved products such as Wegovy, Ozempic, Zepbound, or Mounjaro