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In neoplastic cells, activation of NF-B provides the ability to survive by upregulating anti-apoptotic genes, including several members of the BCL-2 family [192], and increases resistance to chemotherapy by controlling the expression of multidrug resistance gene 1 (mdr1) [193]

Pnp was a key enzyme in the purine remediation pathway, catalyzing the phosphorylation of nucleosides, such as inosine and guanosine and participating in the degradation of ATP [76]

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Each cell has a structure, and this is whats known as the cytoskeleton, made up of tiny protein fibers and tubes

It accomplished this while simultaneously reducing pro-inflammatory cytokines IL-1beta and TNF-alpha and increasing the anti-inflammatory cytokine IL-10