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Recently, a human gene mutation of PAPP-A2, a circulating and tissue protease with IGFBP-5 (and to some extent IGFBP-3) as its primary substrate (Gaudamauskes et al), was demonstrated to have a marked growth phenotype involving fetal and post-natal growth retardation in children in a consanguineous family (43)

These include flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and central nervous system depression proceeding to respiratory paralysis

You may need an individualized treatment plan along with medication to manage sciatic pain

However, these findings are based on preclinical studies, and the effectiveness of BPC 157 in humans is still under investigation

Women should consult their healthcare provider about appropriate timing for discontinuation, as the medication has a half-life of approximately 5 days with elimination occurring over several weeks