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The variations in ROS generation could affect the amounts of oxidized proteins, lipids, and DNA damage, increasing the colons vulnerability to GI disorders at these two intestinal sites (129)

10.1002/9781394258932.ch22 52 FernandesA.Miller-FlemingL.PaisT

SF, prime among these phytochemical options, has now been the subject of at least eight clinical studies, many of them now completed, some of them already published, and all of the published outcomes except one [194] showed beneficial effects [71,80,195,196,197,198,199,200]

Levine RL, Williams JA, Stadtman EP, Shacter E (1994) [37] Carbonyl assays for determination of oxidatively modified proteins

Lancet 381 , 18351843