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The combination amplifies the harmful effects of each substance and can lead to a spiraling pattern of dependency, reinforcing the use of one when consuming the other

Lastly, nicotine also has peripheral vasoconstrictive or bronchoconstrictive effects ( Finally, the Amazonian epistemic concepts that play a role in tobacco-based treatments as per our informant are consistent with traditional Amazonian conceptions of healing and sickness in general (e.g., concept of plants with agency, concept of spiritual/energetic factors in pathogenesis and treatment

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