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For example, depletion of striatal DA via the neurotoxin 6-hydroxy-dopamine in rats produces aphagia and akinesia

The DiGeorge syndrome , also called velocardiofacial or 22q11.2 deletion syndrome (22q11.2DS), is caused by a hemizygous microdeletion (1.53 Mb) on chromosome 22 DiGeorge syndrome The prevalence rate of this condition is ~1 in 4000 [356]

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This is the main neuropeptide, that when that goes haywire, the consequences are traumatic sleep gets affected, pain gets affected, and melanocytes stimulating hormone controls