Translation Failure Pattern: Dramatic rodent results repeatedly fail to replicate in humans

HYGIENE A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES A61K38/00Medicinal preparations containing peptides Landscapes Health & Medical Sciences (AREA) Chemical & Material Sciences (AREA) Organic Chemistry (AREA) Life Sciences & Earth Sciences (AREA) General Health & Medical Sciences (AREA) Medicinal Chemistry (AREA) Animal Behavior & Ethology (AREA) Veterinary Medicine (AREA) Public Health (AREA) Pharmacology & Pharmacy (AREA) Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA) General Chemical & Material Sciences (AREA) Chemical Kinetics & Catalysis (AREA) Bioinformatics & Cheminformatics (AREA) Engineering & Computer Science (AREA) Biochemistry (AREA) Neurosurgery (AREA) Molecular Biology (AREA) Gastroenterology & Hepatology (AREA) Genetics & Genomics (AREA) Toxicology (AREA) Proteomics, Peptides & Aminoacids (AREA) Neurology (AREA) Biomedical Technology (AREA) Biophysics (AREA) Endocrinology (AREA) Heart & Thoracic Surgery (AREA) Cardiology (AREA) Zoology (AREA) Reproductive Health (AREA) Pulmonology (AREA) Psychology (AREA) Diabetes (AREA) Hematology (AREA) Dermatology (AREA) Gynecology & Obstetrics (AREA) Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA) Medicinal Preparation (AREA) Peptides Or Proteins (AREA) Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA) Description Die vorliegende Erfindung betrifft neue Anwendungsformen von synthetischen BPC(Body Protection Compound)-Peptiden, die 8 bis 15 Aminosurereste umfassen, mit einem Molekulargewicht von 900 bis 1600 Dalton, die eine organprotektive Wirkung aufweisen, Verfahren zu ihrer Herstellung und ihre Verwendung in der Diagnose und Therapie

12 13 Therapeutic Potential : In sleep medicine, modulating orexin pathways is a promising strategy for addressing conditions such as insomnia and excessive wakefulness
The glutathione-bound toxic substance can then be excreted in the urine, sweat, or feces.[ref] Glutathione S-transferase (GSTM1, GSTP1, etc) detoxification reactions Related article : GST Genetic Variants What depletes your glutathione levels
That is a meaningful standalone number for a compound that most people only ever discuss as an add-on