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Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression

These doses are well tolerated and have no meaningful toxicity risk, as excess B12 is excreted in urine rather than accumulating in tissues

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Exclusion criteria: (1) Patients with abnormal coagulation function [limits: prothrombin time (PT) between 1014 seconds, activated partial thromboplastin time (APTT) between 2540 seconds, and fibrinogen (Fib) levels between 2.04.0 g/L] and immunodeficiency [either primary immunodeficiency (congenital or hereditary conditions leading to impaired immune responses) or secondary immunodeficiency (conditions acquired through HIV infection, chronic immunosuppressive therapy, or severe malnutrition)]