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As a triple agonist , it simultaneously activates three distinct receptor systems [5]: GIP (Glucose-dependent Insulinotropic Polypeptide) receptors enhance insulin secretion and may have direct effects on adipose tissue GLP-1 (Glucagon-like Peptide-1) receptors promote satiety, slow gastric emptying, and improve glucose regulation Glucagon receptors increase energy expenditure and may enhance fat oxidation This multi-receptor targeting strategy distinguishes retatrutide from single-pathway peptides and creates a complex metabolic profile that researchers are still working to fully characterize

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6) have been identified: (1) NMDA receptors, which bind glutamate and the glutamate analogue N-Methyl-D-Aspartate (NMDA) and (2) non-NMDA receptors, which are selectively agonized by kainate, AMPA, and quisqualate, but not NMDA