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An alternative for patients with COPD who are having difficulty at quitting is that of substituting conventional cigarettes with combustion-free nicotine delivery devices (such as e-cigarettes) and to reduce harm from chronic prolonged cigarette smoke exposure

In contrast, results showed that exclusive use of combustible cigarettes significantly increased the risks for all outcomes, including hypertension, type 2 diabetes, COPD, heart failure, and atherosclerotic cardiovascular disease