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The combination of (-)-Vestitol and Salviolone synergistically regulated more genes and pathways related to AD To elucidate the underlying MOA for the synergistic effects of the combination of (-)-Vestitol and Salviolone, we performed RNA-seq analysis on the cortex of the WT, control, (-)-Vestitol, Salviolone, and combination groups

These methylation changes correlate with corresponding alterations in gene expression, suggesting functional significance for observed epigenetic modifications

[74] analyzed the FAERS data from 2005 to October 2023, revealing a notable incidence of suicidal ideation and depression linked to semaglutide and liraglutide, with no recorded cases of suicidal behaviors or completed suicides

Curr Drug Targets 14(7):733742

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