This work was funded by the National Research, Development and Innovation Office of Hungary, grant numbers NNE-29617 (M-ERA.NET2 nanoPD) and K143766 (for M.A.D.)
doi: 10.1186/s12964-021-00799-8
Most published clinical data comes from AOD-9604, not the unmodified fragment
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However, following the supplementation of NAD +, the related damage was reversed by means of upregulating SIRT1 and SIRT3 activity, which resulted in increased mitochondrial complex content and activity, in addition to improved liver FAO and oxidative stress (Gariani et al
