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Furthermore, interventional studies in DSS-colitis suggest targeting ferroptosis could be therapeutic: -caryophyllene inhibition of macrophage lipid peroxidation and ferroptosis was linked to suppression of inflammation [12], and seliciclib-treated micethat displayed reduced epithelial ferroptosishad less severe DSS-induced colitis [41]

Bile acids can trigger mitochondrial ROS generation in hepatocytes that in turn act to mediate the inactivation of PTPs, resulting in the activation of EGFR (90)

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By delivering antioxidants, mitochondrial boosters, hormonesupporting vitamins, and immune-modulating agents directly into the bloodstream, it may improve egg and sperm quality, hormonal balance, luteal phase stability, and IVF successparticularly in difficult fertility cases