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[DOI] [PubMed] [Google Scholar] 9.Busch SA, Silver J

L.SchultzA.et al

Endogenous and exogenous cannabinoids, including nabilone, may have potential therapeutic benefits for improving sleep and relieving pain and mood disorders in PD patients through their effects on various neurotransmitter systems, including monoaminergic, GABAergic, glutamatergic, and opioid signaling

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In its natural form, PEA is not absorbed by the gastrointestinal tract. Coluzzi points out you must purchase PEA that has been ultra-micronized, which is a process that reduces the particle size to enhance absorption