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Other studies have found that the activation of NLRP3 can recruit and activate pro-inflammatory protease caspase-1, and then produce IL-1, IL-18 and other cytokines, triggering a process of inflammation-relatedcell death named pyroptosis

Beta-carotene taken up into enterocytes in this way is then cleaved into retinaldehyde through the action of the -carotene oxygenase encoded by the BCO1 gene

All animal experiments were carried out upon approval of the Institutional Animal Care and Use Committee of Harbin Institute of Technology University

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"Guidelines on food fortification with micronutrients" (PDF)