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Thus were the conclusions made in a 2015 paper published in Cell Metabolism , in which the authors noted that MOTS-c has physiological similarities to the first-line diabetes drug metformin with regard to managing glucose utilization, metabolism, and body weight.18 Reduced body fat Considering the effects that MOTS-c has on insulin response and glucose uptake two factors associated with weight gain the authors of the 2015 paper referenced above also examined the peptides potential for preventing obesity.19 Specifically, in a group of mice fed a high-fat diet, MOTS-c appeared to prevent obesity onset.18 Other studies have corroborated these results by finding that higher plasma MOTS-c levels are negatively correlated with obesity.20 Improved physical performance Recall that endogenous MOTS-c can be activated by exercise, allowing your skeletal muscles to use glucose for energy to meet their high energy demand

Interestingly, the pattern of change in these metabolic genes (280 and 550 at 24 h and 48 h, respectively

Daniel Chille highlighted that the gut microbiome comprises over 50% of our cells and impacts multiple organs and immunity (32:23) He evaluates Firmicutes to Bacteroides ratios, secretory IgA levels, and mucosal barrier health to assess dysbiosis

Lanphear BP, Matte TD, Rogers J, Clickner RP, Dietz B, Bornschein RL, Succop P, Mahaffey KR, Dixon S, Galke W, Rabinowitz M, Farfel M, Rohde C, Schwartz J, Ashley P, Jacobs DE (1998) The contribution of lead-contaminated house dust and residential soil to childrens blood lead levels

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