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Fundamentally, aging is driven by the cumulative effects of cellular senescence ( The strategies to address senescent cells and replenish exhausted stem cells during the aging process, as well as supplementing metabolic substances like NAD+, gene therapy, or epigenetic approaches to mitigate aging, are different because they aim to promote the repair of senescent cells rather than inducing their apoptosis ( The Forkhead box O (FOXO) proteins are an important subclass of the Forkhead family

these strategies are all still in their infancy As 50% of patients with PD have comorbid Alzheimer disease (AD) pathology, targeting of tau and amyloid- could open novel avenues to alleviate or halt cognitive dysfunction Disease-modifying therapies under investigation in AD could also be of benefit in PD

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