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Understanding cellular redox homeostasis: a challenge for precision medicine

Variability in how individuals handle drugsdue to genetics, disease states like renal or hepatic insufficiency, age, or drug interactionscan lead to significant differences in plasma concentrations from a given dose, resulting in either therapeutic failure or adverse events

A volume of 5 l of 1.5% v/v DMSO and 2% v/v DMSO in respective buffers for GSTO1 and PDI were used as DMSO controls

studied the sensitivity of tumor cells to mitochondrial ETC inhibitors and found that tumor cells insensitive to ETC inhibition maintain intracellular Asp concentrations through the Asp/glutamate transporter SLC1A3, which gives tumor cells a survival advantage

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