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Methodologically, research paradigms should be innovated to improve theoretical alignment and methodological rigor, employing novel approaches such as longitudinal tracking designs and big data analytics to examine prevention messages behavior change mechanisms and actual effectiveness from multiple angles

C., Tynan, M

Multiple observations have also supported early impairments in arterial stiffness following acute consumption of ENDS containing nicotine [24, 30, 80], even after very short periods of usage [82]

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Hair tests are reliable for long term tobacco use and are primarily used to detect cotinine, maintaining a high level of accuracy for 3 months after stopping smoking and able to detect nicotine use from the hair for up to a year after starting smoking cessation