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R The clinical relevance for detoxification: Met/Met individuals have reduced capacity to methylate and inactivate catechol estrogens (2-OH and 4-OH estradiol)

Mitochondrial dysfunction in fragile X syndrome and fragile X-associated tremor/ataxia syndrome: prospect use of antioxidants and mitochondrial nutrients

IcmF from Cupriavidas metallodurans is an AdoCbl-dependent isobutyryl-CoA mutase fused (IcmF), in which the MeaB domain exists as an independent domain of the target enzyme, which itself harbors two domains, an N-terminal TIM barrel-shaped substrate binding domain and a C-terminal Rossman fold AdoCbl-binding domain (Figure 42B)