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The thinking is they work through different mechanisms and may have synergistic effects

HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3

It is also about which genes get expressed and which go silent

STAT3 is a crucial factor in maintaining cell proliferation and survival, and can be activated by various cytokines to mediate immune and inflammatory responses (Wu X