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There are great concerns that many children in low and middle-income countries fail to reach their developmental potential due to poverty-related factors such as malnutrition, micronutrient deficiencies, parental illiteracy, and lack of stimulation and learning opportunities

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Many mass-market supplements contain "flow agents" like magnesium stearate or silicon dioxide, along with artificial flavors and colors

Perturbations of metabolic status within the pathway as ROS-processing activity increases could contribute to oxidant-triggered signalling