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However, marijuana that is smoked is often unfiltered, which can potentially lead to more damaging particles entering the airways and lungs. All groups were compared to nonsmokersand those who smoked both were found to be 12 times more likely to have centrilobular emphysema, which can lead to difficulty breathing, coughing, and other respiratory symptoms

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Advances in Asthma: Pathophysiology, Diagnosis and Treatment Springer (2018)

because of the missing data on bupropion, it is also not possible to draw conclusions about the benefit of such combinations

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