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An experimental model of prolonged esophagitis with sphincter failure in the rat and the therapeutic potential of gastric pentadecapeptide BPC 157

105 Thus it is reasonable to offer cystoscopy to men and women over the age of 50, since the odds of identifying Hunner lesions are higher in this age group, and the potential benefits of identifying Hunner patients and directing them to more effective therapies (see Statement 19) outweigh the potential risks

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However, higher doses increase cost without established evidence of proportionally increased benefit