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They are commonly upregulated as an adaptive response of the skin to harmful factors including environmental toxins such as PAHs present in large quantities in cigarette smoke 25

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GHB quickly crosses the blood-brain barrier and exerts central nervous effects, primarily on monoaminergic synapses, affecting dopamine and specific GHB receptors

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Tobacco control policymakers can learn from the already identified tactics and strategies used by TTCs to successfully penetrate and establish their position in both LMICs and HICs 6-9