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Research on AD models has suggested that reactive astrocytes are more susceptible to neuronal reprogramming than their nonreactive counterparts, underscoring the role of astrocytic heterogeneity in influencing cell differentiation 25,149

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Notably, in the datasets specifically focusing on spontaneous abortion within the European population, a total of 95 valid genetic instruments were included in the MR analysis (Table S2)

In rats, the KA-SE model also exhibits a decrease in reduced glutathione (GSH) and an increase in its oxidized form (GSSG), indicating increased ROS burden post seizure activity

G protein activation via GPCRs has long been thought to occur exclusively at the plasma membrane (PM)