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Studies in IGF-IR-deficient mice demonstrate that these mice die within a few days after birth [34], indicating that IGF-IR has critical roles in development and health

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For colorectal cancer, Hao et al.s study (2020) demonstrated SFNs potential as a chemopreventive agent (Figure 4), acting through the modulation of the ERK/Nrf2 pathway and impacting cell proliferation, apoptosis, and migration [76]