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doi: 10.1016/j.drudis.2016.09.024, 201

& Weaver, J

In some instances, upon administration of a controlled release auris formulation or composition described herein, drug concentrations relative to the binding constants of two receptors, such as, by way of example only, mineralcorticoid receptor (MR) and glucocorticoid receptor (GR), are relevant in determining the C min or the biologically most meaningful PK profile

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Animal studies first established efficacy comparable to 5% minoxidil, with documented increases in follicle size noted as early as 1993 research