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The incidence of sporadic ALS (SALS) in the 1990s in Europe and North America ranged from 1.5 to 2.7 per 100000 inhabitants per year, with an equal incidence in these regions (Wijesekera and Leigh 2009)

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In this regard, sustained chronic fat consumption induces mitochondrial -oxidation of free fatty acids and resulted to excess electron flow using cytochrome c oxidase, which promotes ROS levels

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(2020) indicated that the expression levels of certain cytochrome P450 enzymes and the conjugating enzyme UGT1 A1 were affected by high-altitude hypoxia 35