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The decreased binding of IGF-1 LR3 to IGFBPs may affect its bioavailability and interactions with specific tissues in research settings

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Amorim T, Khiyami A, Latif T, Fazeli PK

A: It is a naturally occurring peptide originally identified in the CNS, but supplied in synthetic form for research applications

Negatively charged targets are mainly represented by phospholipids, such as PS, which are secluded in the inner side of the plasmatic membrane in normal cells, but increasing the content of PS and accordingly increasing the cancer cell's negative charge allows for the specificity of ACPs (176,177,178)