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A hallmark feature of respiratory viral infections is the induction of glycolysis, particularly in alveolar macrophages, epithelial cells, and infiltrating immune cells such as neutrophils and monocytes, because Glycolysis provides ATP quickly, even in low-oxygen conditions, and supplies intermediates for nucleotide, lipid, and amino acid synthesiscritical for the expansion and function of immune cells like macrophages and T cells (108)

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As a result of cerebral hypoxia and inflammation, massive populations of mesothelial cells are activated in the process of angiogenesis (Vagnucci and Li 2003)