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Third, dose-ranging animal safety studies focused specifically on copper accumulation across repeated systemic dosing would define whether a therapeutic window plausibly exists

It inhibits Th17 cells, decreasing the production of the inflammatory factor IL-17 (148)

FSP1 has received considerable attention in cancer research, with numerous studies (77, 78) examining its expression and function in various tumor cells, finding close associations with apoptosis and antitumor effects

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ERAP1 (IC50 = 900 nM) and 15-fold improved selectivity vs