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Surgical specimen underwent histopathological examination, which showed spindle-shaped epithelioid cells with eosinophilic cytoplasm carrying abundant melanin and scattered psammoma bodies

Our research group has previously shown that the gross pathology, histopathology, GAG content, and MMP-2 activity of human and canine IVDs were similar in all different stages of IVD degeneration [9]

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These observations have led to the proposal of a gutgonadal axis, which may represent a future research direction in dairy cattle