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A woman can lose up to 30% of her collagen in the first five years of menopause, leading to sagging skin, wrinkles, and pigmentation

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For instance, Casgevy, based on the CRISPR/Cas9 gene-editing system, was the first successful attempt at disease treatment, promising a one-time treatment for a lifelong effect. However, the complexity of clinical applications and the difficulty of target selection in gene editing have led to long treatment cycles and high costs

Nat Neurosci (2021) 24(2):16875

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