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Devices that vaporize higher-nicotine liquids fall under the definition of new products subject to FDA review, according to the 2016 regulation

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In old age (table 4) the difference between cigarette smokers and non-smokers in the probability of a 70 year old surviving to 90 increased from only 2% (10% 12%) at the death rates seen during the first decade of the study (among men born, on average, around 1875) to 26% (7% 33%) at the death rates seen during the fifth decade of the study (among men born, on average, around 1915), indicating that the corresponding difference will be still greater for those born in the 1920s