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The logic here is that the underlying pathology is not resolving as cleanly as an acute mechanical injury, and ongoing mucosal protection may require sustained peptide signaling

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GHK-Cu activates the TGF-/Smad signaling pathwaythe most potent endogenous stimulator of collagen productionwhile simultaneously enhancing production of connective tissue growth factor (CTGF) and FGF-2 that further amplify collagen expression