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Yet dissecting the specific involvement of this signalling in models carrying m HTT is challenging, as m HTT causes various dysfunctions, including that of BDNF-TrkB signalling

Upon tissue disruption, danger-associated molecular patterns (DAMPs) Such as extracellular ATP, high-mobility group box 1 (HMGB1), and uric acid crystals are released from damaged cells [26, 27], while PAMPs from the wound microbiome including lipopolysaccharide (LPS) from Gram-negative bacteria, lipoteichoic acid from Gram-positive bacteria, and bacterial DNA-are detected by pattern recognition receptors (PRRs) such as NLRP3, AIM2, or NLRC4 [28]

Another important concern of ours is Vitamin B12 which seems to be a fundamental bodily nutrient that helps in the production of energy