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Therapeutic Value of Ginkgo biloba Extract EGb 761(R) in an Animal Model (Meriones unguiculatus) for Noise Trauma Induced Hearing Loss and Tinnitus

Critical safety thresholds have been established for compounds like EGCG (800 mg/day limit) (240) and -carotene (contraindicated in smokers), while hepatotoxicity cases linked to curcumin formulations have prompted regulatory warnings across multiple jurisdictions

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DSIP functions through mechanisms that are not fully characterized but appear to involve modulation of sleep-wake regulatory centers in the brain and interactions with various neurotransmitter systems