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63 Urea Cycle Enzyme Deficiency Reduced activity of one or more enzymes of the urea cycle may result in elevated blood ammonia concentration.10, 64 Serum bile acids levels should remain within reference range in patients with urea cycle enzyme deficiencies

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Higher concentrations are not necessarily more effective GHK-Cu operates through receptor-mediated signaling rather than dose-dependent saturation

Ethics statement The animal study was reviewed and approved by The institutional animal care and use committee of the University of Putra Malaysia on 20 October 2017 with no UPM/ACUC/AUP-RO75/2017

Also review whether other factors might be causing breakouts