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NAD+ (nicotinamide adenine dinucleotide), an essential coenzyme present in all living cells, activates sirtuins and supports DNA repair, mitochondrial function, and metabolic regulation -- touching multiple hallmarks simultaneously

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Neuroinflammation may have an important role, sustained by aberrant crosstalk between neurons and glial cells

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However, some researchers argue that short peptides like EpitalON may retain activity when taken orally